Guild Wars 2 tells the tale of the rise of the Elder Dragons of Tyria, the last chance for all nations to come together to save their world--but most importantly, it is the story of YOU, the player within that world, and the heroic adventures and tales you experience in this amazingly expansive world. Our philosophy is that the player is the most important part of the game. ArenaNet is bringing to life a massive world of events, storylines, and characters - all we need is you. So now I just have to ask you one thing... What is your story?
-- Guild Wars 2 Personal Story Overview
The core Guild Wars has a generically "fantasy" look and feel, without being decidedly influenced by any particular real-world culture or historical period. There are four playable races, each with their own culture and artistic/visual theme.
Guild Wars 2 fantasy artwork galleries